Agmatine MIP Biosensor (RUO)
The Agmatine MIP Biosensor is a highly selective, ultra-sensitive electrochemical sensor engineered for rapid quantification of agmatine, a key metabolite involved in nitric oxide signaling, polyamine metabolism, neuroinflammation, and bacterial infection pathways.
Using Fluidome’s proprietary molecularly imprinted polymer (MIP) technology, this biosensor delivers antibody-like molecular selectivity with the robustness, stability, and cost efficiency of synthetic “plastic antibodies.”
The agmatine sensor integrates directly with standard electrochemical readout systems and is compatible with Fluidome’s microfluidic MIP-Chip platform for automated sample-to-answer workflows.
Detection can be performed directly from serum or urine, with demonstrated nanomolar sensitivity and LC–MS–validated accuracy.
Key Features
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Ultrasensitive nanomolar detection (LOD 0.1 nM)
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Wide linear detection range: 1 nM – 100 µM
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Rapid assay time (5–10 minutes)
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High selectivity using a tailored MIP binding cavity
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Validated for serum and urine
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Electrode-only or microfluidic MIP-Chip formats
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High reproducibility (RSD ~2% with QC)
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Long-term storage stability (>12 weeks at 4°C)
Applications
Validated and demonstrated applications include:
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Quantification of agmatine in serum and urine
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Bacterial infection diagnostics (agmatine as a metabolic signature)
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Neuroinflammation and neurodegeneration research
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Studies of nitric oxide and polyamine metabolic pathways
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Metabolomics assay development
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Real-time metabolite monitoring in microfluidic systems
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Method development in electrochemical biosensing
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High-throughput metabolite profiling (RUO)
Packaging and Specifications
Packaging material: Polypropylene tube or microfluidic cartridge
Sterility: Not sterilized
Packaging: 1 biosensor per package
Format options: Electrode-only / integrated microfluidic chip
Assay time: 5–10 minutes
Technology: MIP-based electrochemical biosensor
Transduction: SWV, CV, EIS compatible
LOD: 0.1 nM
Linear range: 1 nM – 100 µM
Sample types: Serum, urine
Stability: High stability for ≥12 weeks at 4°C
Reproducibility: RSD 2.05% (QC group) vs. 9.68% (control)
Shipping conditions: Room temperature
Recommended storage: 4°C (short-term) or refrigeration (long-term)
Regulatory status: Research Use Only (RUO)—not for diagnostic use
Analytical Performance
Documented analytical performance from published and internal studies:
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Strong agreement with LC–MS quantification (validated using Fluidome Metabolite Standard Mix)
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High recovery in plasma (97–102% across multiple spike levels)
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High selectivity and minimal cross-reactivity
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Stable electrochemical performance after long-term refrigerated storage
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RSD reduced from 9.68% → 2.05% using Fluidome’s QC-integrated fabrication
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Reliable linear response from nanomolar to high micromolar concentrations
Technical Note
A MIP-engineered electrochemical biosensor enabling rapid, nanomolar-level quantification of agmatine in serum and urine. Designed for bacterial infection diagnostics, metabolic pathway studies, neuroinflammation research, and general-purpose metabolomics method development.
Important Notes
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The Agmatine Biosensor is Research Use Only (RUO) and not intended for clinical diagnosis.
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Multi-analyte packs (succinate + lactate + agmatine, etc.) are available.
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Custom MIP fabrication or microfluidic integration is available (MIP-Chip format).
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Bulk orders and OEM integration options available upon request.
