The mortality rate of Bloodstream Infection (BSI) increases by 8% for each hour the antibiotic treatment is delayed, and those patients who receive the wrong antibiotic over this period, face a ten-fold increase in mortality. Also, rapid analyzing blood samples for bacterial resistance is also a critical step in reducing the mortality risk posed by a BSI. On the other hand, established clinical bioassays to isolate and detect bacteria and perform antibiotic susceptibility testing (AST) are cost-intensive, tedious and need a large amount of sample volume (10–30 mL), and are time-consuming, typically requiring 3-5 day.

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